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In the UK, EIA is notifiable by law under the Infectious Diseases of Horses Order 1987. Under the Order, anyone who owns, manages, inspects or examines a horse which is affected or is suspected of being affected by the disease must notify the Department for Environment, Food and Rural Affairs (Defra) via the local Field Service office of the Animal & Plant Health Agency (APHA). A list of APHA regional contact telephone numbers appears in Appendix 1 and also on Defra's website.

Under the Order, Defra may declare the premises where disease is suspected to be as an infected place and impose restrictions on horses at those premises. A veterinary enquiry will be carried out under the direction of the RVL of the APHA to determine if EIA is present. The Order also provides Defra with powers to enforce measures for vector control and disinfection.

As there is currently no cure for EIA, any horse testing positive will be subject to compulsory slaughter and disposal under the control of the RVL of the APHA, without compensation. The Equine Infectious Anaemia (Compensation) (England) Order 2006 stipulates compensation to the value of £1 per animal for horses subject to compulsory slaughter for EIA.